ISCHAEMIA COMPLICATING INJURY

Acute ischaemia complicating limb trauma.

DeBakey and Simeone (1946) found that 686 per cent of amputations among United States troops in the second world war were done as the result of arterial trauma. Amputation was required in 4O 3 per cent of cases of arterial trauma. Arterial injuries associated with fractures showed a 50 per cent loss of limb with reparative measures, whereas there was a 70 per cent loss of limb when the vessel w...

Splenic injury complicating ERCP

Endoscopic retrograde cholangiopancreatography (ERCP) is an invasive procedure which carries a complication rate of 5-10%. Splenic injury is a very rare and potentially lethal complication following ERCP. We report a case of a 64-year-old man with a mass at the pancreatic head and obstructive jaundice, who sustained a splenic injury following ERCP. Six hours after the procedure, the patient pre...

Vascular ischaemia and reperfusion injury.

Although restoration of blood flow to an ischaemic organ is essential to prevent irreversible tissue injury, reperfusion per se may result in a local and systemic inflammatory response that may augment tissue injury in excess of that produced by ischaemia alone. Cellular damage after reperfusion of previously viable ischaemic tissues is defined as ischaemia-reperfusion (I-R) injury. I-R injury ...

Ischaemia-Reperfusion-Induced Kidney Injury

HDAC9 exacerbates endothelial injury in cerebral ischaemia/reperfusion injury

Histone deacetylase (HDAC) 9, a member of class II HDACs, regulates a wide variety of normal and abnormal physiological functions, which is usually expressed at high levels in the brain and skeletal muscle. Although studies have highlighted the importance of HDAC-mediated epigenetic processes in the development of ischaemic stroke and very recent genome-wide association studies have identified ...